Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers

• मुख्य लेखकों: Maokai Xu (लेखक), Maria Antonova (लेखक), Pavel Salavei (लेखक), Katharina Illek (लेखक), Ana Valeria Meléndez (लेखक), Ramin Omidvar (लेखक), Roland Thuenauer (लेखक), Olga Makshakova (लेखक), Winfried Römer (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-01-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand-receptor pair based on a dimeric, engineered derivative of the <i>Pseudomonas aeruginosa</i> lectin LecA, here termed Di-LecA, and the host c...