Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers

• Asıl Yazarlar: Maokai Xu (Yazar), Maria Antonova (Yazar), Pavel Salavei (Yazar), Katharina Illek (Yazar), Ana Valeria Meléndez (Yazar), Ramin Omidvar (Yazar), Roland Thuenauer (Yazar), Olga Makshakova (Yazar), Winfried Römer (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2023-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand-receptor pair based on a dimeric, engineered derivative of the <i>Pseudomonas aeruginosa</i> lectin LecA, here termed Di-LecA, and the host c...