Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers

• Hoofdauteurs: Maokai Xu (Auteur), Maria Antonova (Auteur), Pavel Salavei (Auteur), Katharina Illek (Auteur), Ana Valeria Meléndez (Auteur), Ramin Omidvar (Auteur), Roland Thuenauer (Auteur), Olga Makshakova (Auteur), Winfried Römer (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2023-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand-receptor pair based on a dimeric, engineered derivative of the <i>Pseudomonas aeruginosa</i> lectin LecA, here termed Di-LecA, and the host c...