Dimeric Lectin Chimeras as Novel Candidates for Gb3-Mediated Transcytotic Drug Delivery through Cellular Barriers

• Autores principales: Maokai Xu (Autor), Maria Antonova (Autor), Pavel Salavei (Autor), Katharina Illek (Autor), Ana Valeria Meléndez (Autor), Ramin Omidvar (Autor), Roland Thuenauer (Autor), Olga Makshakova (Autor), Winfried Römer (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2023-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Receptor-mediated transcytosis is an elegant and promising strategy for drug delivery across biological barriers. Here, we describe a novel ligand-receptor pair based on a dimeric, engineered derivative of the <i>Pseudomonas aeruginosa</i> lectin LecA, here termed Di-LecA, and the host c...