Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype

• Main Authors: Val A. Fajardo (Author), Eric Bombardier (Author), Elliott McMillan (Author), Khanh Tran (Author), Brennan J. Wadsworth (Author), Daniel Gamu (Author), Andrew Hopf (Author), Chris Vigna (Author), Ian C. Smith (Author), Catherine Bellissimo (Author), Robin N. Michel (Author), Mark A. Tarnopolsky (Author), Joe Quadrilatero (Author), A. Russell Tupling (Author)
• Format: Book
• Published: The Company of Biologists, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Centronuclear myopathy (CNM) is a congenital myopathy that is histopathologically characterized by centrally located nuclei, central aggregation of oxidative activity, and type I fiber predominance and hypotrophy. Here, we obtained commercially available mice overexpressing phospholamban (PlnOE), a...