Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol

• 主要な著者: Joyce S. Macwan (著者), Grace Fraczkiewicz (著者), Mauro Bertolino (著者), Phillip Krüger (著者), Sheila‐Annie Peters (著者)
• フォーマット: 図書
• 出版事項: Wiley, 2021-06-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Abstract Merck KGaA observed slight differences in the dissolution of Concor® (bisoprolol) batches over the years. The purpose of this work was to assess the impact of in vitro dissolution on the simulated pharmacokinetics of bisoprolol using in vitro-in vivo relationship established with available...