Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol

• Principais autores: Joyce S. Macwan (Autor), Grace Fraczkiewicz (Autor), Mauro Bertolino (Autor), Phillip Krüger (Autor), Sheila‐Annie Peters (Autor)
• Formato: Livro
• Publicado em: Wiley, 2021-06-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Merck KGaA observed slight differences in the dissolution of Concor® (bisoprolol) batches over the years. The purpose of this work was to assess the impact of in vitro dissolution on the simulated pharmacokinetics of bisoprolol using in vitro-in vivo relationship established with available...