Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

• मुख्य लेखकों: Maxine J. Roberts (लेखक), Lauren T. May (लेखक), Alastair C. Keen (लेखक), Bonan Liu (लेखक), Terrance Lam (लेखक), Steven J. Charlton (लेखक), Elizabeth M. Rosethorne (लेखक), Michelle L. Halls (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Proliferation of human lung fibroblasts in the pulmonary interstitial tissue is a hallmark of this disease and is driven by prolonged ERK signalling in the nucl...