Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

• Main Authors: Maxine J. Roberts (Author), Lauren T. May (Author), Alastair C. Keen (Author), Bonan Liu (Author), Terrance Lam (Author), Steven J. Charlton (Author), Elizabeth M. Rosethorne (Author), Michelle L. Halls (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Proliferation of human lung fibroblasts in the pulmonary interstitial tissue is a hallmark of this disease and is driven by prolonged ERK signalling in the nucl...