Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

• Glavni autori: Maxine J. Roberts (Autor), Lauren T. May (Autor), Alastair C. Keen (Autor), Bonan Liu (Autor), Terrance Lam (Autor), Steven J. Charlton (Autor), Elizabeth M. Rosethorne (Autor), Michelle L. Halls (Autor)
• Format: Knjiga
• Izdano: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Idiopathic pulmonary fibrosis is a chronic and progressive fibrotic lung disease, and current treatments are limited by their side effects. Proliferation of human lung fibroblasts in the pulmonary interstitial tissue is a hallmark of this disease and is driven by prolonged ERK signalling in the nucl...