Attenuation of toll-like receptor expression and function in latent tuberculosis by coexistent filarial infection with restoration following antifilarial chemotherapy.

• Main Authors: Subash Babu (Author), Sajid Q Bhat (Author), N Pavan Kumar (Author), R Anuradha (Author), Paul Kumaran (Author), P G Gopi (Author), C Kolappan (Author), V Kumaraswami (Author), Thomas B Nutman (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2009-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mycobacterium tuberculosis (Mtb) and filarial coinfection is highly prevalent, and the presence of filarial infections may regulate the Toll-like receptor (TLR)-dependent immune response needed to control Mtb infection. By analyzing the baseline and mycobacterial antigen-stimulated expression of TLR...