Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma

• Hlavní autoři: Hiroo Katsuya (Autor), Lucy B. M. Cook (Autor), Aileen G. Rowan (Autor), Yorifumi Satou (Autor), Graham P. Taylor (Autor), Charles R. M. Bangham (Autor)
• Médium: Kniha
• Vydáno: BMC, 2018-07-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Abstract The prognosis of adult T-cell leukemia-lymphoma (ATL) remains very poor, and there is an urgent clinical need to investigate novel therapies for ATL. The expression of phosphatidylinositol 3-kinase-δ (PI3k-δ) is normally restricted to hematopoietic cells and is known as a key determinant of...