Phosphatidylinositol 3-kinase-δ (PI3K-δ) is a potential therapeutic target in adult T-cell leukemia-lymphoma

• Autors principals: Hiroo Katsuya (Autor), Lucy B. M. Cook (Autor), Aileen G. Rowan (Autor), Yorifumi Satou (Autor), Graham P. Taylor (Autor), Charles R. M. Bangham (Autor)
• Format: Llibre
• Publicat: BMC, 2018-07-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Abstract The prognosis of adult T-cell leukemia-lymphoma (ATL) remains very poor, and there is an urgent clinical need to investigate novel therapies for ATL. The expression of phosphatidylinositol 3-kinase-δ (PI3k-δ) is normally restricted to hematopoietic cells and is known as a key determinant of...