Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice

• Principais autores: Mariaconcetta Durante (Autor), Silvia Sgambellone (Autor), Cecilia Lanzi (Autor), Patrizia Nardini (Autor), Alessandro Pini (Autor), Flavio Moroni (Autor), Emanuela Masini (Autor), Laura Lucarini (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Pulmonary fibrosis is the most frequent form of interstitial lung disease. Effective therapies are not yet available; novel therapeutic approaches are needed for counteracting fibrosis. Poly(ADP-ribose) polymerases are enzymes, involved in DNA repair and cell apoptosis. PARP-1 deficient mice exhibit...