Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice

• Главные авторы: Mariaconcetta Durante (Автор), Silvia Sgambellone (Автор), Cecilia Lanzi (Автор), Patrizia Nardini (Автор), Alessandro Pini (Автор), Flavio Moroni (Автор), Emanuela Masini (Автор), Laura Lucarini (Автор)
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• Опубликовано: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Предметы: article
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Pulmonary fibrosis is the most frequent form of interstitial lung disease. Effective therapies are not yet available; novel therapeutic approaches are needed for counteracting fibrosis. Poly(ADP-ribose) polymerases are enzymes, involved in DNA repair and cell apoptosis. PARP-1 deficient mice exhibit...