Effects of PARP-1 Deficiency and Histamine H4 Receptor Inhibition in an Inflammatory Model of Lung Fibrosis in Mice

• Main Authors: Mariaconcetta Durante (Author), Silvia Sgambellone (Author), Cecilia Lanzi (Author), Patrizia Nardini (Author), Alessandro Pini (Author), Flavio Moroni (Author), Emanuela Masini (Author), Laura Lucarini (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pulmonary fibrosis is the most frequent form of interstitial lung disease. Effective therapies are not yet available; novel therapeutic approaches are needed for counteracting fibrosis. Poly(ADP-ribose) polymerases are enzymes, involved in DNA repair and cell apoptosis. PARP-1 deficient mice exhibit...