Discovery of Small Molecules as Membrane-Bound Catechol-<i>O</i>-methyltransferase Inhibitors with Interest in Parkinson's Disease: Pharmacophore Modeling, Molecular Docking and In Vitro Experimental Validation Studies
A pharmacophore-based virtual screening methodology was used to discover new catechol-<i>O</i>-methyltransferase (COMT) inhibitors with interest in Parkinson's disease therapy. To do so, pharmacophore models were constructed using the structure of known inhibitors and then they were...
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| Main Authors: | , , , , , , |
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| Format: | Book |
| Published: |
MDPI AG,
2021-12-01T00:00:00Z.
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| Subjects: | |
| Online Access: | Connect to this object online. |
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