Evaluation of cytotoxicity and mutagenicity of the benzodiazepine flunitrazepam in vitro and in vivo

• المؤلفون الرئيسيون: Igor Vivian de Almeida (مؤلف), Giovana Domingues (مؤلف), Lilian Capelari Soares (مؤلف), Elisângela Düsman (مؤلف), Veronica Elisa Pimenta Vicentini (مؤلف)
• التنسيق: كتاب
• منشور في: Universidade de São Paulo, 2014-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Flunitrazepam (FNZ) is a sedative benzodiazepine prescribed for the short-term treatment of insomnia. However, there are concerns regarding possible carcinogenic or genotoxic effects of this medicine. Thus, the aim of this study was to evaluate the cytotoxic, clastogenic and aneugenic effects of FNZ...