Evaluation of cytotoxicity and mutagenicity of the benzodiazepine flunitrazepam in vitro and in vivo

• Main Authors: Igor Vivian de Almeida (Author), Giovana Domingues (Author), Lilian Capelari Soares (Author), Elisângela Düsman (Author), Veronica Elisa Pimenta Vicentini (Author)
• Format: Book
• Published: Universidade de São Paulo, 2014-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Flunitrazepam (FNZ) is a sedative benzodiazepine prescribed for the short-term treatment of insomnia. However, there are concerns regarding possible carcinogenic or genotoxic effects of this medicine. Thus, the aim of this study was to evaluate the cytotoxic, clastogenic and aneugenic effects of FNZ...