Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

• Main Authors: Aman P. Singh (Author), Xirong Zheng (Author), Xiefan Lin-Schmidt (Author), Wenbo Chen (Author), Thomas J. Carpenter (Author), Alice Zong (Author), Weirong Wang (Author), Donald L. Heald (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of mechanism-based, multiscale pharmacokinetic-pharmacodynamic (PK-PD) models for chimeric antigen receptor (CAR)-T cells is needed to enable investigation of in vitro and in vivo correlation of CAR-T cell responses and to facilitate preclinical-to-clinical translation. Toward this g...