Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model

• Hoofdauteurs: Aman P. Singh (Auteur), Xirong Zheng (Auteur), Xiefan Lin-Schmidt (Auteur), Wenbo Chen (Auteur), Thomas J. Carpenter (Auteur), Alice Zong (Auteur), Weirong Wang (Auteur), Donald L. Heald (Auteur)
• Formaat: Boek
• Gepubliceerd in: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The development of mechanism-based, multiscale pharmacokinetic-pharmacodynamic (PK-PD) models for chimeric antigen receptor (CAR)-T cells is needed to enable investigation of in vitro and in vivo correlation of CAR-T cell responses and to facilitate preclinical-to-clinical translation. Toward this g...