Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

• Main Authors: Yuta Higashikuse (Author), Nishant Mittal (Author), Takuro Arimura (Author), Sung Han Yoon (Author), Mayumi Oda (Author), Hirokazu Enomoto (Author), Ruri Kaneda (Author), Fumiyuki Hattori (Author), Takeshi Suzuki (Author), Atsushi Kawakami (Author), Alexander Gasch (Author), Tetsushi Furukawa (Author), Siegfried Labeit (Author), Keiichi Fukuda (Author), Akinori Kimura (Author), Shinji Makino (Author)
• Format: Book
• Published: The Company of Biologists, 2019-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by cardiac hypertrophy with diastolic dysfunction. Gene mutations causing HCM have been found in about half of HCM patients, while the genetic etiology and pathogenesis remain unknown for many cases of HCM. To identify novel mec...