Identification and Pharmaceutical Characterization of a New Itraconazole Terephthalic Acid Cocrystal

• Main Authors: Ricardo Machado Cruz (Author), Tereza Boleslavská (Author), Josef Beránek (Author), Eszter Tieger (Author), Brendan Twamley (Author), Maria Jose Santos-Martinez (Author), Ondřej Dammer (Author), Lidia Tajber (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The crystallization of poorly soluble drug molecules with an excipient into new solid phases called cocrystals has gained a considerable popularity in the pharmaceutical field. In this work, the cocrystal approach was explored for a very poorly water soluble antifungal active, itraconazole (ITR), wh...