In Vitro Stimulation of Multidrug Resistance-Associated Protein 2 Function Is Not Reproduced In Vivo in Rats

• Main Authors: Ravindranath Reddy Gilibili (Author), Vishwanath Kurawattimath (Author), Bokka Venkata Murali (Author), Yurong Lai (Author), T. Thanga Mariappan (Author), Hong Shen (Author), Sagnik Chatterjee (Author)
• Format: Book
• Published: MDPI AG, 2018-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Previously we reported that coproporphyrin-I (CP-I) is an optimal probe substrate for multidrug resistance-associated protein 2 (MRP2), and stimulation of MRP2-mediated transport is probe substrate-dependent. In the present investigation, we assessed if the in vitro stimulation is physiologically re...