Pharmacological and Genetic Suppression of VDAC1 Alleviates the Development of Mitochondrial Dysfunction in Endothelial and Fibroblast Cell Cultures upon Hyperglycemic Conditions

• Main Authors: Konstantin N. Belosludtsev (Author), Dmitriy A. Serov (Author), Anna I. Ilzorkina (Author), Vlada S. Starinets (Author), Mikhail V. Dubinin (Author), Eugeny Yu. Talanov (Author), Maxim N. Karagyaur (Author), Alexandra L. Primak (Author), Natalia V. Belosludtseva (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prolonged hyperglycemia related to diabetes and its complications leads to multiple cellular disorders, the central one being the dysfunction of mitochondria. Voltage-dependent anion channels (VDAC) of the outer mitochondrial membrane control the metabolic, ionic, and energy cross-talk between mitoc...