Pharmacological and Genetic Suppression of VDAC1 Alleviates the Development of Mitochondrial Dysfunction in Endothelial and Fibroblast Cell Cultures upon Hyperglycemic Conditions

• Автори: Konstantin N. Belosludtsev (Автор), Dmitriy A. Serov (Автор), Anna I. Ilzorkina (Автор), Vlada S. Starinets (Автор), Mikhail V. Dubinin (Автор), Eugeny Yu. Talanov (Автор), Maxim N. Karagyaur (Автор), Alexandra L. Primak (Автор), Natalia V. Belosludtseva (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2023-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Prolonged hyperglycemia related to diabetes and its complications leads to multiple cellular disorders, the central one being the dysfunction of mitochondria. Voltage-dependent anion channels (VDAC) of the outer mitochondrial membrane control the metabolic, ionic, and energy cross-talk between mitoc...