Applicability of generic assays based on liquid chromatography-electrospray mass spectrometry to study in vitro metabolism of 55 structurally diverse compounds

• Главные авторы: Timo Rousu (Автор), Juho Hokkanen (Автор), Olavi R Pelkonen (Автор), Ari Tolonen (Автор)
• Формат: ‌
• Опубликовано: Frontiers Media S.A., 2010-08-01T00:00:00Z.
• Предметы: article
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Liquid chromatography-mass spectrometry (LC/MS) with generic gradient elution for a large number of chemically different compounds is a common approach in drug development, used to acquire a large amount of data in a short time frame for drug candidates. The analysis with non-optimised parameters ho...