MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate

• मुख्य लेखकों: Sara Abdelfatah (लेखक), Angela Berg (लेखक), Qi Huang (लेखक), Li Jun Yang (लेखक), Sami Hamdoun (लेखक), Anette Klinger (लेखक), Henry J. Greten (लेखक), Edmond Fleischer (लेखक), Thorsten Berg (लेखक), Vincent K.W. Wong (लेखक), Thomas Efferth (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2019-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory fu...