MCC1019, a selective inhibitor of the Polo-box domain of Polo-like kinase 1 as novel, potent anticancer candidate

• Main Authors: Sara Abdelfatah (Author), Angela Berg (Author), Qi Huang (Author), Li Jun Yang (Author), Sami Hamdoun (Author), Anette Klinger (Author), Henry J. Greten (Author), Edmond Fleischer (Author), Thorsten Berg (Author), Vincent K.W. Wong (Author), Thomas Efferth (Author)
• Format: Book
• Published: Elsevier, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Polo-like kinase (PLK1) has been identified as a potential target for cancer treatment. Although a number of small molecules have been investigated as PLK1 inhibitors, many of which showed limited selectivity. PLK1 harbors a regulatory domain, the Polo box domain (PBD), which has a key regulatory fu...