Antimicrobial activity and mechanism of action of Nu-3, a protonated modified nucleotide

• Main Authors: Wang Ming (Author), Sun Lun-Quan (Author), Cao Shanping (Author)
• Format: Knjiga
• Izdano: BMC, 2011-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>"Nubiotics" are synthetic oligonucleotides and nucleotides with nuclease-resistant backbones, and are fully protonated for enhanced ability to be taken up by bacterial cells. Nu-3 [butyl-phosphate-5'-thymidine-3'-...