Antimicrobial activity and mechanism of action of Nu-3, a protonated modified nucleotide

• Auteurs principaux: Wang Ming (Auteur), Sun Lun-Quan (Auteur), Cao Shanping (Auteur)
• Format: Livre
• Publié: BMC, 2011-01-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>"Nubiotics" are synthetic oligonucleotides and nucleotides with nuclease-resistant backbones, and are fully protonated for enhanced ability to be taken up by bacterial cells. Nu-3 [butyl-phosphate-5'-thymidine-3'-...