Vitamin C Cytotoxicity and Its Effects in Redox Homeostasis and Energetic Metabolism in Papillary Thyroid Carcinoma Cell Lines

• Main Authors: Laura Tronci (Author), Gabriele Serreli (Author), Cristina Piras (Author), Daniela Virginia Frau (Author), Tinuccia Dettori (Author), Monica Deiana (Author), Federica Murgia (Author), Maria Laura Santoru (Author), Martina Spada (Author), Vera Piera Leoni (Author), Julian Leether Griffin (Author), Roberta Vanni (Author), Luigi Atzori (Author), Paola Caria (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High-dose of vitamin C (L-ascorbic acid, ascorbate) exhibits anti-tumoral effects, primarily mediated by pro-oxidant mechanisms. This cytotoxic effect is thought to affect the reciprocal crosstalk between redox balance and cell metabolism in different cancer types. Vitamin C also inhibits the growth...