2-Phenoxy-3-Trichloromethylquinoxalines Are Antiplasmodial Derivatives with Activity against the Apicoplast of <i>Plasmodium falciparum</i>

• Autores principales: Dyhia Amrane (Autor), Christophe-Sébastien Arnold (Autor), Sébastien Hutter (Autor), Julen Sanz-Serrano (Autor), Miguel Collia (Autor), Amaya Azqueta (Autor), Lucie Paloque (Autor), Anita Cohen (Autor), Nadia Amanzougaghene (Autor), Shahin Tajeri (Autor), Jean-François Franetich (Autor), Dominique Mazier (Autor), Françoise Benoit-Vical (Autor), Pierre Verhaeghe (Autor), Nadine Azas (Autor), Patrice Vanelle (Autor), Cyrille Botté (Autor), Nicolas Primas (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2021-07-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

The malaria parasite harbors a relict plastid called the apicoplast. Although not photosynthetic, the apicoplast retains unusual, non-mammalian metabolic pathways that are essential to the parasite, opening up a new perspective for the development of novel antimalarials which display a new mechanism...