Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues

• 主要な著者: Francesca Nuti (著者), Maud Larregola (著者), Agnieszka Staśkiewicz (著者), Bernhard Retzl (著者), Nataša Tomašević (著者), Lorenzo Macchia (著者), Maria E. Street (著者), Michał Jewgiński (著者), Olivier Lequin (著者), Rafal Latajka (著者), Paolo Rovero (著者), Christian W. Gruber (著者), Michael Chorev (著者), Anna Maria Papini (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters. To increase the stability of OT by replacing the disulphide bridge with the stable...