Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues

• Main Authors: Francesca Nuti (Author), Maud Larregola (Author), Agnieszka Staśkiewicz (Author), Bernhard Retzl (Author), Nataša Tomašević (Author), Lorenzo Macchia (Author), Maria E. Street (Author), Michał Jewgiński (Author), Olivier Lequin (Author), Rafal Latajka (Author), Paolo Rovero (Author), Christian W. Gruber (Author), Michael Chorev (Author), Anna Maria Papini (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters. To increase the stability of OT by replacing the disulphide bridge with the stable...