Mutation-Based Antibiotic Resistance Mechanism in Methicillin-Resistant <i>Staphylococcus aureus</i> Clinical Isolates
β-Lactam antibiotics target penicillin-binding proteins and inhibit the synthesis of peptidoglycan, a crucial step in cell wall biosynthesis. <i>Staphylococcus aureus</i> acquires resistance against β-lactam antibiotics by producing a penicillin-binding protein 2a (PBP2a), encoded by the...
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