Mutation-Based Antibiotic Resistance Mechanism in Methicillin-Resistant <i>Staphylococcus aureus</i> Clinical Isolates

• Main Authors: Tanveer Ali (Author), Abdul Basit (Author), Asad Mustafa Karim (Author), Jung-Hun Lee (Author), Jeong-Ho Jeon (Author), Shafiq ur Rehman (Author), Sang-Hee Lee (Author)
• Format: Book
• Published: MDPI AG, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

β-Lactam antibiotics target penicillin-binding proteins and inhibit the synthesis of peptidoglycan, a crucial step in cell wall biosynthesis. <i>Staphylococcus aureus</i> acquires resistance against β-lactam antibiotics by producing a penicillin-binding protein 2a (PBP2a), encoded by the...