IRAK4 inhibition: an effective strategy for immunomodulating peri-implant osseointegration via reciprocally-shifted polarization in the monocyte-macrophage lineage cells

• Главные авторы: Juan Zhao (Автор), Jia Li (Автор), Antian Xu (Автор), Yangbo Xu (Автор), Fuming He (Автор), Yingjie Mao (Автор)
• Формат: ‌
• Опубликовано: BMC, 2023-05-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Abstract Background The biomaterial integration depends on its interaction with the host immune system. Monocyte-macrophage lineage cells are immediately recruited to the implant site, polarized into different phenotypes, and fused into multinucleated cells, thus playing roles in tissue regeneration...