Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend <i>C. elegans</i> Life- and Healthspan

• Автори: Samuel Kakraba (Автор), Srinivas Ayyadevara (Автор), Nirjal Mainali (Автор), Meenakshisundaram Balasubramaniam (Автор), Suresh Bowroju (Автор), Narsimha Reddy Penthala (Автор), Ramani Atluri (Автор), Steven W. Barger (Автор), Sue T. Griffin (Автор), Peter A. Crooks (Автор), Robert J. Shmookler Reis (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2023-10-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer's disease, cardiomyopathy, and cancer. One of the age-associated processes underlying chronic inflammation is protein aggregation, which is implicated in neuroinflammation and a broad...