Thiadiazolidinone (TDZD) Analogs Inhibit Aggregation-Mediated Pathology in Diverse Neurodegeneration Models, and Extend <i>C. elegans</i> Life- and Healthspan

• Main Authors: Samuel Kakraba (Author), Srinivas Ayyadevara (Author), Nirjal Mainali (Author), Meenakshisundaram Balasubramaniam (Author), Suresh Bowroju (Author), Narsimha Reddy Penthala (Author), Ramani Atluri (Author), Steven W. Barger (Author), Sue T. Griffin (Author), Peter A. Crooks (Author), Robert J. Shmookler Reis (Author)
• Format: Book
• Published: MDPI AG, 2023-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic, low-grade inflammation has been implicated in aging and age-dependent conditions, including Alzheimer's disease, cardiomyopathy, and cancer. One of the age-associated processes underlying chronic inflammation is protein aggregation, which is implicated in neuroinflammation and a broad...