Understanding effect site pharmacology of uprifosbuvir, a hepatitis C virus nucleoside inhibitor: Case study of a multidisciplinary modeling approach in drug development

• Principais autores: Paul van den Berg (Autor), Wei Gao (Autor), Maurice J. Ahsman (Autor), Leticia Arrington (Autor), Filippos Kesisoglou (Autor), Randy Miller (Autor), Teun M. Post (Autor), Matthew L. Rizk (Autor)
• Formato: Livro
• Publicado em: Wiley, 2021-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Uprifosbuvir is a uridine nucleoside monophosphate prodrug inhibitor of the hepatitis C virus NS5B RNA polymerase. To quantitatively elucidate key metabolic pathways, assess the link between unmeasurable effect site concentrations and viral load reduction, and evaluate the influence of intr...