Understanding effect site pharmacology of uprifosbuvir, a hepatitis C virus nucleoside inhibitor: Case study of a multidisciplinary modeling approach in drug development

• Main Authors: Paul van den Berg (Author), Wei Gao (Author), Maurice J. Ahsman (Author), Leticia Arrington (Author), Filippos Kesisoglou (Author), Randy Miller (Author), Teun M. Post (Author), Matthew L. Rizk (Author)
• Format: Book
• Published: Wiley, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Uprifosbuvir is a uridine nucleoside monophosphate prodrug inhibitor of the hepatitis C virus NS5B RNA polymerase. To quantitatively elucidate key metabolic pathways, assess the link between unmeasurable effect site concentrations and viral load reduction, and evaluate the influence of intr...