Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists

• Main Authors: Lei Sun (Author), Zhi-Ming Zheng (Author), Chang-Sheng Shao (Author), Zhi-Yong Zhang (Author), Ming-Wei Li (Author), Li Wang (Author), Han Wang (Author), Gen-Hai Zhao (Author), Peng Wang (Author)
• Format: Book
• Published: MDPI AG, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Glucagon-like peptide-1 (GLP-1) is easily degraded by dipeptidyl peptidase-4 (DPP-4) in the human body, limiting its therapeutic effect on type II diabetes. Therefore, improving GLP-1 receptor agonist (GLP-1RA) stability is a major obstacle for drug development. We analyzed human GLP-1, DPP-4, and G...