Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists

• Κύριοι συγγραφείς: Lei Sun (Συγγραφέας), Zhi-Ming Zheng (Συγγραφέας), Chang-Sheng Shao (Συγγραφέας), Zhi-Yong Zhang (Συγγραφέας), Ming-Wei Li (Συγγραφέας), Li Wang (Συγγραφέας), Han Wang (Συγγραφέας), Gen-Hai Zhao (Συγγραφέας), Peng Wang (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: MDPI AG, 2022-06-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

Glucagon-like peptide-1 (GLP-1) is easily degraded by dipeptidyl peptidase-4 (DPP-4) in the human body, limiting its therapeutic effect on type II diabetes. Therefore, improving GLP-1 receptor agonist (GLP-1RA) stability is a major obstacle for drug development. We analyzed human GLP-1, DPP-4, and G...