Rational Design by Structural Biology of Industrializable, Long-Acting Antihyperglycemic GLP-1 Receptor Agonists

• Asıl Yazarlar: Lei Sun (Yazar), Zhi-Ming Zheng (Yazar), Chang-Sheng Shao (Yazar), Zhi-Yong Zhang (Yazar), Ming-Wei Li (Yazar), Li Wang (Yazar), Han Wang (Yazar), Gen-Hai Zhao (Yazar), Peng Wang (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2022-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Glucagon-like peptide-1 (GLP-1) is easily degraded by dipeptidyl peptidase-4 (DPP-4) in the human body, limiting its therapeutic effect on type II diabetes. Therefore, improving GLP-1 receptor agonist (GLP-1RA) stability is a major obstacle for drug development. We analyzed human GLP-1, DPP-4, and G...