Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models

• Main Authors: Alexander Denninger (Author), Tim Becker (Author), Ulrich Westedt (Author), Karl G. Wagner (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2023-07-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive transport, prodrug activation, and first-pass me...