Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy

• Main Authors: Shurong Zhou (Author), Ting Su (Author), Furong Cheng (Author), Janet Cole (Author), Xiang Liu (Author), Bei Zhang (Author), Shaheer Alam (Author), Jinze Liu (Author), Guizhi Zhu (Author)
• Format: Book
• Published: Elsevier, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Activating cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) holds great potential for cancer immunotherapy by eliciting type-I interferon (IFN-I) responses. Yet, current approaches to cGAS-STING activation rely on STING agonists, which suffer from difficult formulation, poor pharm...