Engineering cGAS-agonistic oligonucleotides as therapeutics for cancer immunotherapy

• Autori principali: Shurong Zhou (Autore), Ting Su (Autore), Furong Cheng (Autore), Janet Cole (Autore), Xiang Liu (Autore), Bei Zhang (Autore), Shaheer Alam (Autore), Jinze Liu (Autore), Guizhi Zhu (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2024-03-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Activating cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) holds great potential for cancer immunotherapy by eliciting type-I interferon (IFN-I) responses. Yet, current approaches to cGAS-STING activation rely on STING agonists, which suffer from difficult formulation, poor pharm...