Gold complex compounds that inhibit drug-resistant Staphylococcus aureus by targeting thioredoxin reductase

• Autori principali: Nagendran Tharmalingam (Autore), Shi Xu (Autore), Lewis Oscar Felix (Autore), Biswajit Roy (Autore), Ming Xian (Autore), Eleftherios Mylonakis (Autore), Beth Burgwyn Fuchs (Autore)
• Natura: Libro
• Pubblicazione: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

IntroductionThere is a significant need for new antimicrobial compounds that are effective against drug-resistant microbes. Thioredoxin reductase (TrxR) is critical in redox homeostasis and was identified as a potential drug target and confirmed through inhibition by compounds auranofin and Bay11-70...