Gold complex compounds that inhibit drug-resistant Staphylococcus aureus by targeting thioredoxin reductase

• Main Authors: Nagendran Tharmalingam (Author), Shi Xu (Author), Lewis Oscar Felix (Author), Biswajit Roy (Author), Ming Xian (Author), Eleftherios Mylonakis (Author), Beth Burgwyn Fuchs (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionThere is a significant need for new antimicrobial compounds that are effective against drug-resistant microbes. Thioredoxin reductase (TrxR) is critical in redox homeostasis and was identified as a potential drug target and confirmed through inhibition by compounds auranofin and Bay11-70...