Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of genes. This reduction of heterozygosity creates genetic differences between tumor and normal ce...

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Main Authors: Xiaonan Zhang (Author), Tobias Sjöblom (Author)
Format: Book
Published: MDPI AG, 2021-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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