Targeting Loss of Heterozygosity: A Novel Paradigm for Cancer Therapy

• Những tác giả chính: Xiaonan Zhang (Tác giả), Tobias Sjöblom (Tác giả)
• Định dạng: Sách
• Được phát hành: MDPI AG, 2021-01-01T00:00:00Z.
• Những chủ đề: article
• Truy cập trực tuyến: Connect to this object online.

Loss of heterozygosity (LOH) is a common genetic event in the development of cancer. In certain tumor types, LOH can affect more than 20% of the genome, entailing loss of allelic variation in thousands of genes. This reduction of heterozygosity creates genetic differences between tumor and normal ce...