Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease

• Автори: Peter J. Belmont (Автор), Eva Budinska (Автор), Ping Jiang (Автор), Mark J. Sinnamon (Автор), Erin Coffee (Автор), Jatin Roper (Автор), Tao Xie (Автор), Paul A. Rejto (Автор), Sahra Derkits (Автор), Owen J. Sansom (Автор), Mauro Delorenzi (Автор), Sabine Tejpar (Автор), Kenneth E. Hung (Автор), Eric S. Martin (Автор)
• Формат: Книга
• Опубліковано: The Company of Biologists, 2014-06-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Effective treatment options for advanced colorectal cancer (CRC) are limited, survival rates are poor and this disease continues to be a leading cause of cancer-related deaths worldwide. Despite being a highly heterogeneous disease, a large subset of individuals with sporadic CRC typically harbor re...