Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease

• Main Authors: Peter J. Belmont (Author), Eva Budinska (Author), Ping Jiang (Author), Mark J. Sinnamon (Author), Erin Coffee (Author), Jatin Roper (Author), Tao Xie (Author), Paul A. Rejto (Author), Sahra Derkits (Author), Owen J. Sansom (Author), Mauro Delorenzi (Author), Sabine Tejpar (Author), Kenneth E. Hung (Author), Eric S. Martin (Author)
• Format: Book
• Published: The Company of Biologists, 2014-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Effective treatment options for advanced colorectal cancer (CRC) are limited, survival rates are poor and this disease continues to be a leading cause of cancer-related deaths worldwide. Despite being a highly heterogeneous disease, a large subset of individuals with sporadic CRC typically harbor re...