Expanding DdCBE-mediated targeting scope to aC motif preference in rat

• Main Authors: Xiaolong Qi (Author), Lei Tan (Author), Xu Zhang (Author), Jiachuan Jin (Author), Weining Kong (Author), Wei Chen (Author), Jianying Wang (Author), Wei Dong (Author), Lijuan Gao (Author), Lijun Luo (Author), Dan Lu (Author), Jianan Gong (Author), Feifei Guan (Author), Wenjie Shu (Author), Xingxu Huang (Author), Lianfeng Zhang (Author), Shengqi Wang (Author), Bin Shen (Author), Yuanwu Ma (Author)
• Format: Book
• Published: Elsevier, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An animal model harboring pathogenic mitochondrial DNA (mtDNA) mutations is important to understand the biological links between mtDNA variation and mitochondrial diseases. DdCBE, a DddA-derived cytosine base editor, has been utilized in zebrafish, mice, and rats for tC sequence-context targeting an...